Elanco Highlights Head-to-Head Tick Efficacy Data for Credelio Quattro

Elanco has published new comparative data showing that its canine parasiticide Credelio Quattro achieved a faster speed of tick kill than two competing products in head-to-head studies, adding to evidence supporting rapid tick control in dogs.

Elanco has announced new head-to-head data indicating that its canine parasiticide Credelio Quattro demonstrated a faster speed of tick kill than competing products Simparica Trio and NexGard Plus in comparative studies published in the peer-reviewed journal Parasites & Vectors.

According to the company, Credelio Quattro, which contains the active ingredient lotilaner alongside moxidectin, praziquantel and pyrantel, significantly reduced black-legged ticks (Ixodes scapularis) within eight hours of infestation and maintained this speed of kill through Day 28 of the monthly dosing interval. Elanco also cited previously published data showing that lotilaner achieved the fastest initial kill of lone star ticks (Amblyomma americanum), with efficacy observed within 12 hours.

The findings are positioned against a backdrop of expanding tick populations and increasing concern over tick-borne diseases affecting both animals and humans. Elanco noted that rapid tick kill is considered an important factor in reducing the risk of pathogen transmission, although disease prevention depends on multiple factors, including the specific pathogen and timing of transmission.

Credelio Quattro is approved in the United States for the prevention of heartworm disease, treatment and control of intestinal parasites, and monthly protection against fleas and ticks. The product also carries an FDA-approved claim for the prevention of Lyme disease in dogs as a direct result of killing black-legged ticks.

The newly reported results add comparative efficacy data to the growing body of evidence supporting oral combination parasiticides in the companion animal market.